Evaluation of Antispasmodic Activity of Petroleum Ether Extract of Seeds of Apium graveolens Linn(PEESAG) on Acetylcholine Induced Contraction in Guinea Pigs Ileum- An experimental study

نویسندگان

  • Nisar Ahmed
  • Anzar Alam
چکیده

Background: Apium graveolens Linn. is one of the oldest medicinal plants which used since ancient time in Unani System of Medicine for the disease of gastrointestinal tract which acts as antispasmodic and carminative activity. The aim of this study was to determine the antispasmodic activity of A. graveolens in Guinea Pigs Ileum against acetylcholine induced contractions. Materials and Methods: Antispasmodic activity of PEESAG at the doses of 100, 200, 500, 600, 800 and 900 mcg/ml against acetylcholine at the dose of 10 mcg/ml in guinea pigs. Results: The test drug produced antispasmodic effect 80%, 90% and 100% at the dose of 600, 800 and 900 mcg/ml respectively. Conclusion: This result suggests that the PEESAG revealed antispasmodic activity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Antispasmodic Activity of Petroleum Ether Extract of Seeds of Apium graveolens (PEESAG) on Histamine Induced Contraction in Guinea Pig’s Ileum

Background: Apium graveolens has been used in Unani system of medicine as anti inflammatory, uricosuric, diuretic, carminative, antidyslipidemic, abdominal discomfort etc.The aim of the present study was to determine the antispasmodic activity of A. graveolens in Guinea Pigs against histamine induced contractions. Materials and Methods: Antispasmodic activity of PEESAG at the doses of 100, 200,...

متن کامل

Spasmolytic effect of Anethum graveolens (dill) fruit extract on rat ileum

Introduction: Dill (Anethum graveolens), a herb from from Umbelliferae, is used traditionally to treat convulsion and increasing milk production. Its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. The spasmolytic effect of dill fruit on rat uterus has also been shown recently. The aim of present study was to i...

متن کامل

Relaxant effect of Humulus lupulus extracts on isotonic rat's ileum contractions

O Objective: Many biological studies have been done to determine the activity of medicinal plants on gastrointestinal function. Since acetylcholine is the major transmitter involved in the gastrointestinal motility and there are some evidences regarding the cholinergic modulatory effect of hops extract, in the present study spasmolytic and antispasmodic action of hops(Humulus lupulus) on acetyl...

متن کامل

The Effect of Nonpolar Fraction of Carum Copticum Essence on Acetylcholine Induced Contraction in the Ileum of Isolated Rats

Background and Aims: Our previous study has demonstrated that essence of Carum copticum reduces contraction activity of ileum in rat. The present study was designed to find out the effects of nonpolar fraction of Carum copticum essence (NFCCE) on mechanical activity of the isolated ileum in rat. Materials and Methods: For evaluation of spasmolythic property of fraction, different doses of the ...

متن کامل

Evaluation of Bronchodilator and Anti-Anaphylactic Activity of Myrica sapida

Background: Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Myrica sapida is known traditionally in...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015